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DOI 10.1371/journal.pone.0026182

doi: 10.1038/onc.2016.206 67 BurnstockGDi VirgilioF

Published research examining ipamorelin has employed dosing parameters including: Potency Reference:ED value of 3 nmol/kg in conscious animal models (swine), representing the dose producing 50% maximal growth hormone response Anesthetized rodent studies:ED approximately 8042 nmol/kg in pentobarbital-anesthetized rats Gastrointestinal motility research:Doses of 0140.14 mol/kg intravenous administration in rodent models Cell-based assays:Concentrations ranging from nanomolar to low micromolar levels depending on cell type and endpoint measured Critical Note: All dosing information derives exclusively from controlled preclinical research settings and in-vitro laboratory studies

The findings greatly expand the theoretical and practical foundation for large-molecule drug discovery

& Monaco, C