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No finished-drug approval, no active IND, and no FDA-registered human clinical trials as of April 2026

For analysis of spheroid formation of HCT116 cells, the shRNA-resistant expression vector of FLAG-PGRMC1 or an empty vector was transfected as described above

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The GD group exhibited higher relative abundances in metabolic pathways related to carbohydrate and amino acid metabolism (glycolysis/gluconeogenesis, carbon metabolism, biosynthesis of amino acids), suggesting enhanced microbial metabolic activity

Significant attention has been placed on blocking cystine uptake 17,7276 or cysteine production from methionine via the transsulfuration pathway 9,7779