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A recent study showed that IS increased the expression of interferon regulatory factor 1, which is a downstream AHR gene, and alleviated CKD-associated intestinal dysfunction [103]

Therefore, re-resection, re-irradiation and systemic chemotherapy with TMZ rechallenge, nitrosoureas, bevacizumab, and tumour treating fields (TTF) or clinical trial enrolment to test experimental drugs are considered for all recurrent patients