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Ongoing dryness: Dry skin and lips will likely persist, and some may experience joint stiffness or muscle aches

The thiopurine nucleosides that are formed are transported out of the cell, and thus, the natural function of NT5C2 is to regulate intracellular levels of purine monophosphates, but in the context of thiopurine therapy, it also reduces the amount of 6-TGN available for DNA incorporation (Fig

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Evidence indicates that it exerts inhibitory effects on the axis, thereby maintaining basal stability and limiting exaggerated stress responses