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Activated Caspase-3 cleaves gasdermin E (GSDME), releasing its N-terminal pore-forming domain (PFD) from the C-terminal inhibitory structure, thereby forming membrane pores and inducing GSDME-mediated pyroptosis (46)

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As a result, considerable attention is being devoted to both the type of antigens included in a vaccine, as well as the sequence of antigenic targets

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