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Progestin also thins the lining of the uterus

One systematic review found that 3.6% to 17.1% of patients remained deficient 1 year after surgery despite receiving recommended supplementation (6)

Post-marketing surveillance has not identified increased thyroid cancer rates in human users

In a 2020 case study , researchers reported a young woman treated with multiple daily doses of 1 milligram (mg) of cyanocobalamin (synthetic vitamin B12) for severe pernicious anemia (lack of red blood cells due to vitamin B12 deficiency)