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It is noteworthy that iron metabolism, serving as a bridge linking the microbiota to host pathological processes, exhibits bidirectional regulatory properties: the hosts iron reserve status can significantly influence gut microbiota composition, while specific bacterial strains can reshape host iron distribution by modulating the expression of iron absorption-related proteins

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In addition, higher levels of phosphorylated (active) LKB1 were noted under these conditions in the livers of KO mice but not WT mice (Fig

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