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Nichols S, et al

Chemicals and reagents RSL3 (Selleck, 0.52 M), ferrostatin-1 (Fer-1, Selleck, 25 M), and deferoxamine (DFO, Selleck, 100 M) were dissolved in DMSO and used at indicated concentrations

Nucleophilic attack Attack of an electron-rich species (the nucleophile) on an electron-deficient species (the electrophile), forming a new bond between the nucleophile and the electrophile