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Phase 2 failed primary endpoint Attribute Unique advantage SLU-PP-332 Only pan-ERR agonist with demonstrated in-vivo exercise-mimetic activity MOTS-c Endogenous mitochondrial peptide with AMPK-focused signaling AOD-9604 Most human clinical history of the three Half-life and dose figures across the three compounds are mostly from animal data and should not be read as validated human pharmacology

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Honaker 2008, Hauge 2011 ): avoidance of caffeine, nicotine, red wine, and other migraine triggers stress reduction (see the Stress Management protocol) improving sleep hygiene (see the Insomnia protocol) massage therapy chiropractic manipulation acupuncture getting sufficient exercise and frequent stretching 8 Dietary Interventions A significant association between dietary intake and migraine incidence exists