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Moreover, Gegen Qinlian Decoction reduced the incidence of adverse reactions by 41% ( Compared with 5-ASA monotherapy, the combination strategy with Chinese herbal formulas not only enhanced anti-inflammatory effects but also addressed the limitations of monotherapy across multiple aspects including immunomodulation, mucosal barrier repair, microbiotametabolite balance, microcirculation improvement, and braingut axis regulation, achieving a transition from local anti-inflammation to systemic holistic regulation (Figure 2)