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have reported that restoratrol can alleviate hypoxia-induced neuronal cell death by regulating TRPM2 channel (Li Q

10.1146/annurev.pharmtox.43.100901.135828 48 DerMarderosianA

doi: 10.1021/acs.jmedchem.8b00315 Summary Keywords ferroptosis, lipid metabolism, reactive oxygen species biology, iron homeostasis, immunity, autoimmune diseases Citation Fan J, Jiang T and He D (2023) Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases

Additional studies have shown that spinal fusion may result in degeneration of adjacent discs and lead to further discogenic pain, herniation, stenosis or spondylosis, suggesting that improvements in surgical interventions for back pain are necessary (Ghiselli et al., 2004)