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Int J Mol Sci 21(15):5208

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In high-fat diet-induced obesity models, the GPER agonist G1 reduces body weight and improves insulin sensitivity, highlighting its endocrine-mediated metabolic role [31, 74]

The concern is not that the anti-acne effects cancel out, they likely add up, but that pharmacodynamic overlap means the body is receiving redundant pressure on sebocytes and hepatic detoxification pathways simultaneously