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Finally, emphasis was given to the possible integration of the nanoparticles with other emerging technologies for the symptomatic management of PD

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Its extreme short half-life (minutes) means intranasal or oral routes without modification are ineffective due to rapid degradation

In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis