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The NIH Office of Dietary Supplements recommends that adults over 50 obtain most of their B12 from supplements or fortified foods, since the crystalline form in supplements does not require stomach acid for absorption

Biochem J 332 : 213221

Touched on earlier, another key difference is multiple uses

B12 & Anticonvulsants Patients who frequently use anticonvulsants to treat conditions such as epilepsy are routinely believed to show lowered levels of vitamin B12 within their system