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Atherosclerosis 116 : 147151

doi: 10.1038/s41598-021-95209-x 216 ShawRJAbramsSTAustinJTaylorJMLaneSDuttTet al

The inflammation of the endothelial cells raises the possibility of BBB leakiness, potentially allowing inflammatory mediators, including bacterial products to enter the brain parenchyma and further stimulate microglial immune responses

Over several weeks, dark spots and uneven tone look softer and more even

Specifically, the deletion of TrkB in iSPNs elevated the expression of Gsto2 , thereby leading to increased dopamine levels through alterations of ascorbic acid homeostasis and disruption of energy metabolism in the neurons