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10.1111/cts.13891 6 BarbosaM.ChalmersJ

A., Essner, R

Metformin boosts growth differentiation factor 15 (GDF15) expression , a peptide hormone that helps reduce appetite

One diffusion-tensor imaging study even showed decreased diffusivity in the brainstem and basal ganglia area in ME/CFS patients [129]

Trial registration This trial was retrospectively registered with the University hospital Medical Information Network (UMIN000009366) on November 20, 2012