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Useinov et al., 2020)

This could point toward a possible association between CPT1A activity and dopamine levels

Lyman 2012)

It is the most pharmacologically ambitious incretin molecule in clinical development and produced the largest mean weight reductions ever reported for any obesity drug, exceeding 24% at the highest dose after 48 weeks

While MPHs US Food and Drug Administration (FDA) label does not contain pharmacogenomic biomarkers, a lot of research has been performed on the impact of genotype on MPH efficacy, and several biological pathways have been suggested to potentially affect MPH mechanisms through patient genotype, mostly concerning monoamine pathways [43,44,45,46,47,48]