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H 2 O 2 has a longer half-life and can cross membranes (Sies, 2014), which confers properties to H 2 O 2 as a mitochondrial signal (Raimundo, 2014)

Competing interests MP received honoraria from Novartis, Sanofi, Lundbeck and Celltrion unrelated to the present work

Documenting baseline measurements and taking progress photos every 2-4 weeks provides objective evidence of change that daily mirror checks often miss

These include: Corrective shoeing Estrogen therapy Infusion of a counterirritant or blister As a last resort, medial patellar desmotomy surgery, where the ligament that gets hooked over the femur is cut I have been asked before if a supplement containing silica and collagen would be appropriate for a horse with upward fixation of the patella and my answer is: I dont know

The study is part of the so-called BUPGEN project at Oslo University Hospital