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The entire process is regulated by NF-kB, a master transcription factor that controls the expression of hundreds of inflammatory genes

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Novel modified nucleoside isolated from Escherichia coli phenylalanine transfer ribonucleic acid, Biochemistry , 13 , 2620-2625, Kowalak, J

PARP-1 has been found to interact directly with the RBR-type E3 ubiquitin ligase RNF144A, which promotes PARP-1 self-ubiquitination and proteasome-mediated degradation (Zhang et al., 2017), indicating that E3 ligases can also regulate PARP-1 stability in reverse