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10.1080/08923973.2016.1274997 [DOI] [PubMed] [Google Scholar] Raine T., Bonovas S., Burisch J., Kucharzik T., Adamina M., Annese V., et al

White MF: The IRS-signalling system: a network of docking proteins that mediate insulin action

Thymosin Alpha-1 Thymosin Alpha-1 can modulate immune response and control inflammation

They lack the systemic context necessary to recapitulate inter-organ crosstalk (e.g., hepatic regulation of cardiac copper) and are inherently static, making them unsuitable for modelling the gradual pathogenesis of chronic copper imbalances