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Progressive improvement over subsequent weeks often allows gradual return to running activities that had been impossible

Preliminary biomarker analysis of the INTEGRATE trial showed a similar benefit of regorafenib in patients with VEGF-A levels above and below the median (106)

At the 12 mg dose, clinical trial data showed nausea in 28% of participants, diarrhea in 23%, constipation in 17%, and vomiting in 12%

Some people may also report symptoms such as irritable bowel syndrome (IBS)which can cause abdominal pain, bloating, and changes in bowel habitsand mood disorders, including anxiety and depression