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In the Panels opinion, performing cystoscopy to every IC/BPS patient is not advisable since the benefits/risks ratio is unfavorable for younger patients who have much lower prevalence of Hunner lesions

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Lee, J., Thompson, J

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The study revealed that, in the presence of mutant HTT, a significant portion of genes with altered expression exhibited pronounced changes in DNA methylation, particularly in regions with low CpG content known to undergo methylation changes due to neuronal activity