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Based on our analysis for both the complicated and uncomplicated diagnoses combined with our review of all the cases in the MS-DRGs, we believe the findings support a prior comment, as summarized in the FY 2023 IPPS/LTCH PPS final rule (87 FR 48849), that clinically, both localized and generalized peritonitis in association with an appendectomy require the same level of patient care, including extensive intraoperative irrigation at the surgical site, direct inspection or imaging of the abdomen to identify possible abscess, use of intravenous antibiotics, and prolonged monitoring

The energy and redox components are integrated into an energyredox axis

10.1016/j.beem.2008.10.002 80

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Chowdhury SG, Karmakar P (2023) Revealing the role of epigenetic and post-translational modulations of autophagy proteins in the regulation of autophagy and cancer: a therapeutic approach