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This "crash" in hormones is what often triggers Premenstrual Syndrome (PMS) symptoms like irritability, bloating, and joint sensitivity

Components such as LPS carried by EVs can enter the cytoplasm via the TLR4TRIFGBP3 pathway, activate Caspase-11, and induce inflammation through receptors including TLR2 and NOD1/2 (Gu et al., 2019)