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doi: 10.3389/fphar.2018.01428 67 CarpenterELBeckerALIndraAK

Many drugs have a single mechanism of action and are limited in their effects on complex pathological changes

Chemotherapy-induced peripheral neuropathy in long-term survivors of childhood cancer: clinical, neurophysiological, functional, and patient-reported outcomes

If there is tenderness or swelling in the breast tissue, these could also be signs of gynecomastia

For example, NAPQI, the toxic metabolite, is primarily the product of CYP2E1 metabolism, and there is evidence that younger children have a relative immaturity in CYP2E1 metabolism, which would substantially reduce the production of this toxic metabolite in infants.7 After birth, CYP2E1 protein expression and activity increases, reaching adult levels by about 1 year of age.7 The ability of the liver to metabolize acetaminophen changes with age owing to differences in activity of these key metabolic pathways