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Pediatr Int

Aging impairs protective host defenses against Clostridioides ( Clostridium ) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity

They also suggest that the elevation of homocysteine may have multifactorial effects, interacting with both the vascular wall structure and the blood coagulation system, with different outcomes depending on the tissue and on the consequent degree of hyperhomocysteinemia

Zhang L, Jiang L,Yu L, Li Q, Zeng L,Yang Y, Wang C, Ge X, Gu Q, Li J, Wu D, Sadler AJ,Yu D

At this stage, the therapeutic efficacy of Rg1 remains to be established by further clinical validation, although the initial findings are encouraging