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[42] [43] These properties contribute to the depletion of cysteine from respiratory chain complexes, such as Complexes I and IV, [44] since reactive oxygen species (ROS) produced by the respiratory chain can react with the cysteine residues in these complexes, leading to dysfunctional proteins and potentially contributing to aging

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Reduced antioxidant enzyme activity in ME/CFS Research has revealed that the activity of key antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and GSH peroxidase (GPx) is attenuated in ME/CFS patients, which consequently aggravates oxidative stress

Abstract Homocysteine (Hcy) is an important intermediate product in methionine metabolism which plays a key role in the methylation of DNA, RNA and proteins