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1,61,62 The overactivation of the JAK/STAT pathway has been identified as a key factor in the induction of cytokine release and inflammatory disturbances in a variety of diseases, such as HLH, 63,64,65 aGVHD, 66 CAR-T, 67,68 COVID-19, 69 and FM-associated CS

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Interestingly, our in vivo results evidenced that SeNPs daily topical application at both doses resulted in a reduction in plaque formation, erythema, and scaling