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A comprehensive network meta-analysis of 55 studies identified combinations including rabeprazole, bismuth, furazolidone, and tetracycline as the most effective, while lansoprazole-based regimens had the best safety profile (Wei et al., 2025)

Interestingly, host T cell immune response was needed to inhibit HO-1 by SnPPIX, and SnPPIX failed to reduce bacterial growth and activity of Mtb HO-1 enzyme in broth culture (192)

In cell-based assays, ARA-290 is applied to cultured neuronal cell lines, primary Schwann cells, and pancreatic islet preparations to study receptor binding kinetics and intracellular signaling responses including STAT3 and NF-kB pathway modulation