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J Clin Invest 1999;104:1257-64.ArticlePubMedPMC 32

71 NAC also appears to have a balancing effect on neurotransmitter dysregulation, in particular glutamate homeostasis

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Thyroid hormone resistance, rare condition where tissues require higher than normal thyroid hormone levels for adequate function, should be considered if very high doses prove necessary for symptom control and optimal response

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