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For instance, the expression of adhesion proteins on the surface of (i) MM cells (e.g., CD56, CD49d, and CD138) (101) or of (ii) non-immune and endothelial cells (e.g., CD31/PECAM1) (102) resident in the BM niche are transferred, resulting in diminished expression

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You could also consider a SAMe supplement, but bear in mind it is a medicine in some countries, and there is some evidence that it can imbalance the system and downregulate endogenous SAMe synthesis