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doi: 10.1007/s12035-017-0695-z 45 MaggeRSDeAngelisLM

However, a meta-analysis study examining the efficiency of antioxidants on the initiation and progression of diabetic kidney disease revealed that antioxidants, including CoQ 10 , did not have reliable effects against this disease (Bolignano et al., 10 (1200 mg/day) lowered F2-isoprostane plasma levels indicative of a reduction in oxidative stress (Rivara et al., 2017)

SeornsMGalloVCalvoMVFontechaJ

doi: 10.1159/000548568 36 EstevinhoM

Besides the increase in melanin content, AL lesions are characterized by epidermal alterations such as proliferation/differentiation disbalance or mitochondrial dysfunction, dermal photoaging marks, and disorganization of the dermal extracellular matrix (ECM) [21,22,23]. In particular, AL lesions present an impairment of the cutaneous structure with a marked elongation of the dermalepidermal junction (DEJ), an accumulation of melanin in the epidermis, especially in the rete ridges [21]