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The pathophysiology of doxorubicin and ischemia/reperfusion-induced myocardial injury in mice may be primarily associated with increased mitochondrial iron levels and lipid peroxidation, suggesting that mitochondrial oxidative damage is a principal mechanism underlying ferroptosis in this context [107]

1367-C LONG-TERM FOLLOW-UP OF PATIENTS WITH INCIDENTALLY DETECTED ASYMPTOMATIC HEPATITIS B Mithun Sharma 1 , Anand V

This could contribute to immune cell hyperactivation and inflammatory responses

It also involves pro-inflammatory signaling pathways

Apart from autophagy, several other cell signalling pathways are affected by anti-cancer drugs, contributing to their toxic effects