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Mechanistic Insights & Splice-Variant Biology Mechanistic research indicates that the E-domain (C-terminal) region of IGF-1Ec may localize to nuclei, modulate transcriptional responses, and influence cell survival pathways distinct from traditional IGF-1 signaling

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This phenotype was explored in both mouse models and in vitro with an anti-IL-23 antibody to block IL-23 signaling where mice experienced prolonged survival and decreased tumor burden, and CD8 + cells in mice and in vitro showed enhanced cytotoxicity in the IL-23-depleted state [154] (Fig

Fanelli S, et al

And we're actually also, I think on the cusp of, you know, elucidating blood biomarkers that correlate even more strongly than the blood mar markers that we already have