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In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

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Animal toxicology signals Two animal findings reviewed by FDA are worth tracking even if they did not surface clinically

Some notice gradual improvement over days

No published data exists on longer treatment durations, repeated cycles, or chronic dosing