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Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep

4.6 Relationship between cholinergic system abnormalities and ferroptosis in AD 4.6.1 Relationship between abnormal acetylcholine synthesis/degradation and ferroptosis in AD Cholinergic neurons are widely distributed in the human brain and play crucial roles in neurogenesis, neuronal differentiation, and synaptic plasticity (Long and Holtzman, 2019)

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ROS accumulation triggers OS, cellular damage, mitochondrial dysfunction, A deposition, Tau hyperphosphorylation, synaptic loss, and neuronal deathkey factors in AD progression (Aliev et al., 2004