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otherwise, it may reduce the affinity and change the conformation of the proteins, preventing the target protein to bind to the residues as expected

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90 Modification patterns used in clinical studies or for commercial siRNA Early siRNA therapeutic programs typically employ partial or slight modifications by using 2-OMe, 2-F or PS, 91,92 e.g., alternative 2-OMe modifications were placed in the antisense strand of QPI-1007, whereas just one L-DNA was used in the sense strand