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In summary, beneficial Clostridium and their metabolites exert multifaceted protective effects in eight major ADs by regulating gut-immune crosstalk, reinforcing intestinal barrier integrity, and alleviating disease-specific pathological damage, holding great promise as a complementary strategy for clinical immunotherapy

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The MACE prediction model also utilized a pre-trained BERT model with an added dimensionality reduction layer to transform the unstructured code sequences of each patients diagnostic and medication codes into different-dimensional continuous numeric vector representations(128d, 256d, 512d, 768d)

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