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However, neuroimaging studies showed that white matter networks are defective in preclinical AD, at a time when neurodegenerative changes, cortical atrophy, or cortical glucose reduction were not apparent [33]

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Studies, including those by Altemani et al (Altemani et al., 2021), have shown that reduced levels of butyrate-producing bacteria, such as Coprococcus, compromise intestinal barrier integrity, leading to metabolic endotoxemia, a condition where bacterial toxins like lipopolysaccharides (LPS) enter systemic circulation

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