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Why this trial matters : First ADC to move into the 1L HER2+ metastatic setting Breaks a decade-long treatment paradigm in first-line breast cancer care Confirms ADCs as frontline platforms, not just late-line salvage therapies Roche Giredestrant Delivers the First Phase III Win for an Oral SERD in Early Breast Cancer Roches oral SERD giredestrant reduced the risk of invasive disease recurrence versus standard endocrine therapy in the Phase III lidERA trial in ER-positive, HER2-negative early breast cancer, marking the first major advance in adjuvant endocrine therapy in decades

Cyclin-dependent kinase 7 promotes th17/th1 cell differentiation in psoriasis by modulating glycolytic metabolism

293 T cells were transfected with Slc7a11 overexpression plasmid and cells without transfection were used as control

J Am Coll Surg 2002

MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors