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the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use

Yanguas-Cass, N., Barreda-Manso, M

In summary, ferroptosis, an iron-dependent form of programmed cell death, is closely linked to iron metabolism imbalance, lipid peroxidation, and antioxidant system dysfunction

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Analysis of the dataset in Gene Expression Omnibus (GEO) showed that SLC7A11 and SLC3A2 are two ferroptosis-related genes regulated by estrogen (Fig