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Clinical studies on microneedling with topical treatments show 82% higher response rates compared to topical application alone (Dhurat et al

10.1093/toxsci/kfq394 19 DeleriveP.De BosscherK.BesnardS.Vanden BergheW.PetersJ

Ethics declarations Ethics approval and consent to participate All animal experiments were complied with the ARRIVE guidelines and performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals

Vitamin K-dependent proteins such as osteocalcin and matrix Gla protein are crucial to many physiological processes such as bone mineralization, vascular calcification, and cardiovascular health

In the tumor microenvironment, macrophages frequently exhibiting DNA damage promote immune escape by secreting immunosuppressive factors such as IL-10 and TGF-, whereas during aging, persistent DNA damage in macrophages alters their secretory phenotype, fostering chronic inflammatory conditions in tissues (Fig