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Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome

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Similarly, 5-methoxytryptophan (5-MTP) inhibits fibroblast-to-myofibroblast transition and ECM protein expression by downregulating TGF-/Smad3 and PI3K/AKT pathways, thereby limiting fibroblast proliferation and migration [113]

Figure 4 5.10 Summary of ferroptosis-targeted therapeutic strategies Based on the disease-specific discussions above, ferroptosis-targeted therapeutic strategies can be categorized into three main approaches based on their mechanisms of action: Iron Chelators (e.g., Deferoxamine, Deferiprone) sequester labile iron to limit Fenton chemistry-driven hydroxyl radical generation