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10.1093/carcin/bgt026 123 SongP.LiS.WuH.GaoR.RaoG.WangD.et al (2016)

Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients

EClinicalMedicine 78:102957

It also improves blood pressure, lipid profile, and has antimicrobial properties on bad bacteria in the gut microbiome

In non-enzymatic lipid peroxidation, when initial PLOOH (phospholipid hydroperoxides) are generated and not promptly reduced by the enzyme GPX4, they can react with ferrous ions, leading to the generation of alkoxyl and peroxyl radicals through the Fenton reaction