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Recent studies also identified Yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) as key mechanoresponsive factors in the Hippo pathway to transmit blood flow-induced mechanical forces into intracellular signaling to affect EC phenotypes [223]

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The reduced specificity between the third base of the codon and the complementary nucleotide in anticodon is responsible for wobbling (Table 2) Proline has 4 codons(5-3CCU, CCC, CCA, CCG) The first three codons can be recognized by a single t RNA having Inosine in the first place

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