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research is financially supported by the ke Wiberg Foundation (M23-0040) and Tore Nilsson Foundation (2023-079)

ISSN 1555-9041

In such high throughput assays, it is possible to screen up to several thousand different modulators or ligands in a single day

In two of the OPM-2 xenografts, BSO+L-PAM reduced tumor volumes of 1330 mm 3 and 972 mm 3 to 2), inducing CRs in majority of the mice treated (21/25), achieving MCRs in 6/25 mice, and doubling the median EFS relative to L-PAM alone ( P 80% was not cytotoxic, whereas three cell lines were affected by BSO