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Common US protocols adapt the Russian framework to typical clinic schedules

B) Quantitative PCR analysis of Gdf11 expression in isolated hippocampi from Gdf11 flox/flox , Gdf11 cKO , and CAG-Cre ER

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A common cycling pattern is 4 weeks on, 4 weeks off to prevent tachyphylaxis, though continuous daily use has been studied in clinical trials for up to 14 days with good tolerability [2]

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