glutathione fe3+ ncbi peroxidase gsh-px on iron Lipid Peroxidation and Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis Glutathione Nature-Inspired Bioactive Compounds: A Promising

Nature Inspired Bioactive Compounds: A Promising Approach for Ferroptosis Linked Human Diseases? Oncology Letters Core Molecular Pathways Driving Ferroptosis Ferroptosis is a regulated form of cell death defined by iron dependent lipid peroxidation. Its execution requires the convergence of iron metabolism, oxidative stress, and polyunsaturated lipid remodeling Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. Computational discovery of novel GPX4 inhibitors from herbal sources as potential ferroptosis inducers in cancer therapy ScienceDirect

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