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Hair greying is not listed as a recognised symptom of B12 deficiency in UK clinical guidelines, and testing for B12 deficiency solely for hair greying is not routinely indicated without other compatible symptoms or risk factors

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It is commonly referred to as the worlds worst pain. Patients typically experience attacks of acute, electric shock-like facial discomfort along the trigeminal nerve

One case of heterogeneity is due the up regulation in endothelial cells, associated with tumours, of the PI3K/AKT pathway which has been reported in some intra tumour endothelial cells [72] , one of the consequences is the variable response to angiogenic factors like VEGF and to their blockage [73]