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For maintenance, once every 2 weeks to once a month

This rhythm influences wakefulness and sleep patterns, but when the HPA axis becomes dysregulated, it can lead to symptoms like trouble falling and staying asleep, as well as daytime fatigue (or feeling wired and tired)

Because vitamin B12 is a major player in the production of red blood cells, fatigue is a very common symptom of vitamin B12 deficiency

10.1124/dmd.116.070615 11 GianniniG.BaroneM